A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

摘要: Glioma growth and progression depend on a specialized subpopulation of tumour cells, termed stem cells. Thus, cells represent critical therapeutic target, but the molecular mechanisms that regulate them are poorly understood. Hypoxia plays key role in this study we provide evidence hypoxic microenvironment also controls We define detailed signature cell genes, which overexpressed by vascular perinecrotic/hypoxic niches. Mechanistically, show hypoxia regulation phenotype through hypoxia-inducible factor 2α subsequent induction specific including mastermind-like protein 3 (Notch pathway), nuclear activated T 2 (calcineurin pathway) aspartate beta-hydroxylase domain-containing 2. Notably, number these genes belong to pathways regulating phenotype. Consistently, newly formed gliomas associated with worse clinical prognosis. propose maintained within niche, providing functional link between well-established biology. The identification regulators niche points signalling may be used target glioblastoma population.