Pharmacokinetics and pharmacodynamics of sulfamethoxazole and trimethoprim in swimming crabs (Portunus trituberculatus) and in vitro antibacterial activity against Vibrio: PK/PD of SMZ-TMP in crabs and antibacterial activity against Vibrio.
作者： Guihong Fu , Jiahong Peng , Yuan Wang , Shu Zhao , Wenhong Fang
DOI: 10.1016/J.ETAP.2016.06.029
关键词:
摘要: Serious bacterial pathogens have recently become a major cause of massive mortality in swimming crabs (Portunus trituberculatus). In this study, the antibacterial activity against Vibrio and pharmacokinetics (PK) sulfamethoxazole (SMZ)-trimethoprim (TMP) were estimated to explore pharmacokinetics/pharmacodynamics (PK/PD) properties SMZ-TMP combination. The vitro bacteriostatic anti-Vibrio infection combination at various ratios studied. A degree synergism was observed ranging from 50:1 1:5. results showed that MIC50 MIC90 values for different combinations ranges 0.62-5 0.62-10μg/mL, respectively. distribution MIC 1:1 5:1 0.31-5 0.31-10μg/mL, Crabs then fed (at 1:1) six successive times challenged with parahaemolyticus 1×10(5), 1×10(6), 5×10(6) colony forming units (cfu) per crab. number surviving administered ratio greater than given 5:1. addition, tissue absorption (ratios studied through high-performance liquid chromatography (HPLC). 5:1, CmaxSMZ/TMP hemolymph, hepatopancreas, muscle gill 104:1. 0.57:1, 19:1 6:1, contrast, corresponding these tissues 34:1, 0.14:1, 4:1 3:1, TMP better absorbed eliminated more rapidly hepatopancreas gill, hemolymph. volume exceeded SMZ experiments. indicated PK/PD effect Our study suggests may be used control disease aquatic animals.
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