Meta-analysis of Cognitive Performance by Novel Object Recognition after Proton and Heavy Ion Exposures.

摘要: Experimental studies of cognitive detriments in mice and rats after proton heavy ion exposures have been performed by several laboratories to investigate possible risks astronauts exposed cosmic rays space travel patients treated for brain cancers with carbon beams Hadron therapy. However, distinct radiation types doses, tests rodent models used different laboratories, while few considered detailed dose-response characterizations, including estimates relative biological effectiveness (RBE). Here we report on the first quantitative meta-analysis dose response widely novel object recognition (NOR) test, which or memory. Our study reveals that linear linear-quadratic risk (RR) do not provide accurate descriptions. good descriptions doses up 1 Gy are provided exponentially increasing fluence observed an LET dependence similar a classical quality response, peaks near 100-120 keV/µm declines at higher values. Exponential predictions experimental results NOR mixed-beam protons 56Fe, protons, 16O 28Si. RBE limited available X-ray gamma-ray experiments serve as reference radiation. based use data from combined high-energy low-LET suggest modest RBEs, values <8 most ions, <20 data. In addition, consider log-normal model variation subject responses defined levels. The predicts threshold approximately 0.01 NOR-related detriments.