Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction.

作者: Sheila Alcantara Llaguno , Daochun Sun , Alicia M. Pedraza , Elsa Vera , Zilai Wang

DOI: 10.1038/S41593-018-0333-8

关键词:

摘要: … We have previously shown that adult neural stem and early progenitor cells give origin to glioblastoma. Here we systematically assessed the tumor-initiating potential of adult neural …

参考文章(46)
Julieta Aprea, Miki Nonaka-Kinoshita, Federico Calegari, Generation and characterization of Neurod1-CreER(T2) mouse lines for the study of embryonic and adult neurogenesis. Genesis. ,vol. 52, pp. 870- 878 ,(2014) , 10.1002/DVG.22797
Allison M. Bond, Guo-li Ming, Hongjun Song, Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later Cell Stem Cell. ,vol. 17, pp. 385- 395 ,(2015) , 10.1016/J.STEM.2015.09.003
Eric C. Holland, Gregory N. Fuller, Lene Uhrbom, Marc K. Rosenblum, Joseph C. Celestino, Chengkai Dai, Ink4a-Arf Loss Cooperates with KRas Activation in Astrocytes and Neural Progenitors to Generate Glioblastomas of Various Morphologies Depending on Activated Akt Cancer Research. ,vol. 62, pp. 5551- 5558 ,(2002)
D. Friedmann-Morvinski, E. A. Bushong, E. Ke, Y. Soda, T. Marumoto, O. Singer, M. H. Ellisman, I. M. Verma, Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science. ,vol. 338, pp. 1080- 1084 ,(2012) , 10.1126/SCIENCE.1226929
Jason T. Huse, Eric C. Holland, Genetically Engineered Mouse Models of Brain Cancer and the Promise of Preclinical Testing Brain Pathology. ,vol. 19, pp. 132- 143 ,(2009) , 10.1111/J.1750-3639.2008.00234.X
Suzana Herculano-Houzel, Roberto Lent, Isotropic Fractionator: A Simple, Rapid Method for the Quantification of Total Cell and Neuron Numbers in the Brain The Journal of Neuroscience. ,vol. 25, pp. 2518- 2521 ,(2005) , 10.1523/JNEUROSCI.4526-04.2005
Yuan Zhu, Mario I Romero, Pritam Ghosh, Zhengyi Ye, Patrick Charnay, Elizabeth J Rushing, Jamey D Marth, Luis F Parada, Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain Genes & Development. ,vol. 15, pp. 859- 876 ,(2001) , 10.1101/GAD.862101
Eric C. Holland, Joseph Celestino, Chengkai Dai, Laura Schaefer, Raymond E. Sawaya, Gregory N. Fuller, Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice Nature Genetics. ,vol. 25, pp. 55- 57 ,(2000) , 10.1038/75596
Sheila Alcantara Llaguno, Jian Chen, Chang-Hyuk Kwon, Erica L. Jackson, Yanjiao Li, Dennis K. Burns, Arturo Alvarez-Buylla, Luis F. Parada, Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model Cancer Cell. ,vol. 15, pp. 45- 56 ,(2009) , 10.1016/J.CCR.2008.12.006
Cristian Tomasetti, Bert Vogelstein, Variation in cancer risk among tissues can be explained by the number of stem cell divisions Science. ,vol. 347, pp. 78- 81 ,(2015) , 10.1126/SCIENCE.1260825