Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease

摘要: Throughout the evolutionary time, all organisms and species on Earth evolved with an adaptation to consistent oscillations of sunlight darkness, now recognized as 'circadian rhythm.' Single-cellular multisystem use circadian biology synchronize external environment provide predictive changes in cellular homeostasis. Dysregulation has been implicated numerous prevalent human diseases, subsequently targeting machinery may innovative preventative or treatment strategies. Discovery 'peripheral clocks' unleashed widespread investigations into potential roles clock cellular, tissue, organ function healthy diseased states. Particularly, oxygen-sensing pathways (e.g. hypoxia inducible factor, HIF1), are critical for oxygen availability diseases such myocardial ischemia. Recent have identified a connection between rhythm protein Period 2 (PER2) HIF1A that elucidate evolutionarily conserved network can be targeted manipulate metabolic stressed conditions like Understanding link insights subsequent therapeutic strategies patients This review addresses our current understanding light-sensing (PER2), (HIF1A), context ischemia lays groundwork future studies take advantage these two