Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field
作者： Gustavo Paratcha , Fernanda Ledda
DOI: 10.4137/BMI.S0
关键词:
摘要: Trophic factors control cellular physiology by activating specific receptor tyrosine kinases (RTKs). While the over activation of RTK signaling pathways is associated with cell growth and cancer, recent findings support concept that impaired down-regulation or deactivation RTKs may also be a mechanism involved in tumor formation. Under this perspective, molecular determinants inhibition act as tumor-suppressor genes have potential role markers to monitor predict disease progression. Here, we review current understanding physiological mechanisms attenuate discuss evidence implicates deregulation these events cancer.
sagepub.com
la-press.com参考文章(123)
Anindya Dutta, Yong Sun Lee, MicroRNAs: small but potent oncogenes or tumor suppressors. Current opinion in investigational drugs. ,vol. 7, pp. 560- 564 ,(2006)
Antonio D. Cristofano, Barbara Pesce, Carlos Cordon-Cardo, Pier P. Pandolfi, Pten is essential for embryonic development and tumour suppression. Nature Genetics. ,vol. 19, pp. 348- 355 ,(1998) , 10.1038/1235
Antonio Di Cristofano, Marika De Acetis, Andrew Koff, Carlos Cordon-Cardo, Pier P Pandolfi, Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nature Genetics. ,vol. 27, pp. 222- 224 ,(2001) , 10.1038/84879
E.H. Fischer, A Ullrich, R Lammers, B Bossenmaier, D.E. Cool, N.K. Tonks, J Schlessinger, Differential activities of protein tyrosine phosphatases in intact cells. Journal of Biological Chemistry. ,vol. 268, pp. 22456- 22462 ,(1993) , 10.1016/S0021-9258(18)41551-7
Tanita Casci, Matthew Freeman, Control of EGF receptor signalling: lessons from fruitflies. Cancer and Metastasis Reviews. ,vol. 18, pp. 181- 201 ,(1999) , 10.1023/A:1006313122373
Marian S. Blazes, Kathleen R. Cho, Steven I. Wang, Ramon Parsons, Shikha Bose, Lora Hedrick Ellenson, Hironori Tashiro, Jing Li, Rong Wu, Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Research. ,vol. 57, pp. 3935- 3940 ,(1997)
Christine B. F. Thien, Wallace Y. Langdon, Cbl: many adaptations to regulate protein tyrosine kinases Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 294- 307 ,(2001) , 10.1038/35067100
Samar Jasser, W. K.Alfred Yung, Amy Berson, Diana Iliev, Carmen Tornos, Gregory Fujii, Gordon B. Mills, Lee Ellis, Marsha Frazier, Lauren A. Langford, Peter A. Steck, Thaylon Davis, Brad Swedlund, Patricia Troncoso, Cheryl Frye, David H.F. Teng, Raphael E. Pollack, Kipp L. Hansen, Rong Hu, Mark A. Pershouse, Jeff Lee, Adel El-Naggar, Robert Bookstein, Kathryn L. Gumpper, Huai Lin, Scan V. Tavtigian, Vickie L. Vinson, Joseph B. Bolen, MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Research. ,vol. 57, pp. 5221- 5225 ,(1997)
Andrew Berchuck, John I. Risinger, J. Carl Barrett, A. Kate Hayes, PTEN/MMAC1 Mutations in Endometrial Cancers Cancer Research. ,vol. 57, pp. 4736- 4738 ,(1997)
Steven Seelig, Carlos L. Arteaga, Walter King, F. Michael Yakes, Wichai Chinratanalab, Christoph A. Ritter, Herceptin-induced Inhibition of Phosphatidylinositol-3 Kinase and Akt Is Required for Antibody-mediated Effects on p27, Cyclin D1, and Antitumor Action Cancer Research. ,vol. 62, pp. 4132- 4141 ,(2002)