Sex steroids regulate intermediary metabolism in Oreochromis mossambicus.

摘要: The effect of long-term administration testosterone, progesterone, and a synthetic estrogen, diethylstilbestrol (DES), on intermediary metabolism was studied in freshwater fish Oreochromis mossambicus. present study reveals that Des specifically control key enzymes involved carbohydrate, protein lipid the liver O. mossambicus implying general influence sex steroids metabolism. activities malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PDH), isocitrate (ICDH), glucose 6 phosphatase (G-6-Pase), aspartate aminotransferase (AST), alanine (ALT) are either stimulated or inhibited following steroids. vivo i.p. injection intensely testosterone progesterone hyperglycemic, DES is hypoglycemic, lipogenic, antilipogenic (lipolytic) study. It also established amino acid catabolism, mostly alanine, may be major source substrate for gluconeogenesis. A genomic mode action proposed long term treatment, as their sensitive to transcription translation inhibitors.