Determination of isomeric acid dopamine metabolites in human cerebrospinal fluid by mass fragmentography

作者: Leif Bertilsson , Lena Palmér

DOI: 10.1016/0024-3205(73)90076-3

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摘要: Abstract A method for the quantitative determination of isomers 4-hydroxy-3-methoxyphenylacetic acid (HVA) and 3-hydroxy-4-methoxyphenylacetic (iso-HVA) in cerebrospinal fluid (CSF) by mass fragmentography has been developed. The heptafluorobutyryl methyl ester derivations two compounds could not be separated gas chromatography. relative intensity base peak (m/e 333) molecular ion 392) spectra were, however, quite different allowed a separate determination. Contradictory to previous report, it was found that concentration iso-HVA less than 2% HVA level investigated 12 CSF samples from patients with diseases.

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