In vivo voltammetric study of 6-hydroxydopamine-induced neuronal degradation.
作者： Taizo Nakazato , Akitane Akiyama
DOI: 10.1111/J.1471-4159.1988.TB03061.X
关键词:
摘要: Freely moving rats were injected intraventricularly with 200 micrograms of 6-hydroxydopamine (6-OHDA) and examined for transport this substance to the striatum, degradation dopamine (DA) neurons, functional recovery through microcomputer-controlled in vivo voltammetry. Approximately 6 min after injection, 6-OHDA began appear extracellular fluid contralateral striatum. It increased linearly decrease exponentially termination injection. Two hours injection 6-OHDA, a peak at same potential as DA differential pulse voltammogram. persisted approximately 3 days. When intraperitoneally L-3,4-dihydroxyphenylalanine (L-Dopa), conversion L-Dopa was not found 1 week but clearly recognized 5 months behavioral changes arising from they be less hyperactive than after.
sci-hub.se 参考文章(16)
T D Traylor, G R Breese, EFFECT OF 6-HYDROXYDOPAMINE ON BRAIN NOREPINEPHRINE AND DOPAMINE: EVIDENCE FOR SELECTIVE DEGENERATION OF CATECHOLAMINE NEURONS Journal of Pharmacology and Experimental Therapeutics. ,vol. 174, pp. 413- 420 ,(1970)
Zbigniew S. Herman, Krystyna Kmieciak-Kołada, Ryszard Brus, Behaviour of rats and biogenic amine level in brain after 6-hydroxy-dopamine. Psychopharmacology. ,vol. 24, pp. 407- 416 ,(1972) , 10.1007/BF00402535
A. Herz, P. Schubert, G.W. Kreutzberg, K. Reinhold, Selective uptake of 3H-6-hydroxydopamine by neurones of the central nervous system. Experimental Brain Research. ,vol. 17, pp. 539- 548 ,(1973) , 10.1007/BF00234867
Gösta Jonsson, Charlotte Sachs, Uptake and accumulation of 3H-6-hydroxydopamine in adrenergic nerves European Journal of Pharmacology. ,vol. 16, pp. 55- 62 ,(1971) , 10.1016/0014-2999(71)90056-2
M.W Brightman, I Klatzo, Y Olsson, T.S Reese, The blood-brain barrier to proteins under normal and pathological conditions Journal of the Neurological Sciences. ,vol. 10, pp. 215- 239 ,(1970) , 10.1016/0022-510X(70)90151-6
Shao-Pii Onn, Theodore W. Berger, Edward M. Stricker, Michael J. Zigmond, Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: histochemical and neurochemical analysis. Brain Research. ,vol. 376, pp. 8- 19 ,(1986) , 10.1016/0006-8993(86)90894-2
N. J. Uretsky, L. L. Iversen, Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain. Journal of Neurochemistry. ,vol. 17, pp. 269- 278 ,(1970) , 10.1111/J.1471-4159.1970.TB02210.X
T. BENNETT, G. BURNSTOCK, J. L. S. COBB, T. MALMFORS, An ultrastructural and histochemical study of the short-term effects of 6-hydroxydopamine on adrenergic nerves in the domestic fowl British Journal of Pharmacology. ,vol. 38, pp. 802- 809 ,(1970) , 10.1111/J.1476-5381.1970.TB09889.X
John Grayson Richards, Jean-Pierre Tranzer, The ultrastructural localisation of amine storage sites in the central nervous system with the aid of a specific marker, 5-hydroxydopamine. Brain Research. ,vol. 17, pp. 463- 469 ,(1970) , 10.1016/0006-8993(70)90253-2
Oscar S. Gershanik, Richard E. Heikkila, Roger C. Duvoisin, Asymmetric action of intraventricular monoamine neurotoxins. Brain Research. ,vol. 174, pp. 345- 350 ,(1979) , 10.1016/0006-8993(79)90860-6