Comparison of an Antiinflammatory Dose of Ibuprofen, an Analgesic Dose of Ibuprofen, and Acetaminophen in the Treatment of Patients with Osteoarthritis of the Knee

摘要: Abstract Background. The optimal short-term, symptomatic therapy for osteoarthritis of the knee has not been fully determined. Accordingly, we compared efficacy a nonsteroidal antiinflammatory drug, ibuprofen, given in either an dose (high dose) or analgesic (low dose), with that acetaminophen, pure analgesic. Methods. In randomized, double-blind trial, 184 patients chronic pain due to were 2400 1200 mg ibuprofen per day 4000 acetaminophen day. They evaluated after washout period three seven days before beginning study, and again four weeks treatment. major measures outcome included scores on disability scales Stanford Health Assessment Questionnaire (range possible scores, 0 3), visual-analogue at rest while walking, time needed walk 50 ft (15 m), physician's global assessment patient'...