Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects
作者： Yingfang Tian , Michelle L. Apperson , Bradley P. Ander , Dazhi Liu , Boryana S. Stomova
DOI: 10.1016/J.JNEUROIM.2010.09.001
关键词:
摘要: Abstract Using whole genome exon microarrays 120 exons were differentially expressed between medication-free multiple sclerosis (MS) subjects in remission and healthy control (HS) (p |1.2|). These differentiated MS from HS using cluster analyses, principal components analyses (PCAs) cross-validation. In addition, 340 genes (transcripts) predicted to be alternatively spliced compared HS. findings may provide insight into the pathophysiology of potentially prognostic diagnostic biomarkers. However, given that comparisons performed on a very small sample, these preliminary require confirmation much larger independent cohort.
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sci-hub.se 参考文章(63)
Ludger Klein, Matthias Klugmann, Klaus-Armin Nave, V K Tuohy, Bruno Kyewski, Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nature Medicine. ,vol. 6, pp. 56- 61 ,(2000) , 10.1038/71540
Amanda S Solis, Nikki Shariat, James G Patton, Splicing fidelity, enhancers, and disease Frontiers in Bioscience. ,vol. 13, pp. 1926- ,(2008) , 10.2741/2812
T. Zeis, N. Schaeren-Wiemers, J. Kinter, RNA profiling of MS brain tissues. The International MS Journal. ,vol. 15, pp. 51- ,(2008)
Wynn L Walker, Isaac H Liao, Donald L Gilbert, Brenda Wong, Katherine S Pollard, Charles E McCulloch, Lisa Lit, Frank R Sharp, Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patients BMC Genomics. ,vol. 9, pp. 494- 494 ,(2008) , 10.1186/1471-2164-9-494
Brandi Rollins, Maureen V. Martin, Ling Morgan, Marquis P. Vawter, Analysis of whole genome biomarker expression in blood and brain American Journal of Medical Genetics. ,vol. 153, pp. 919- 936 ,(2010) , 10.1002/AJMG.B.31062
Yufeng Shi, Yan Feng, Jiuhong Kang, Chang Liu, Zhenxin Li, Dangsheng Li, Wei Cao, Ju Qiu, Zhengliang Guo, Enguang Bi, Lei Zang, Chuanzhen Lu, Jingwu Z Zhang, Gang Pei, Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nature Immunology. ,vol. 8, pp. 817- 824 ,(2007) , 10.1038/NI1489
A. ACHIRON, A. FELDMAN, M. MANDEL, M. GUREVICH, Impaired Expression of Peripheral Blood Apoptotic-Related Gene Transcripts in Acute Multiple Sclerosis Relapse Annals of the New York Academy of Sciences. ,vol. 1107, pp. 155- 167 ,(2007) , 10.1196/ANNALS.1381.017
Lalit Rane, Nalini Vudattu, Kasia Bourcier, Eva Graniar, Jan Hillert, Vicki Seyfert, M J Maeurer, Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) in peripheral blood from patients with multiple sclerosis (MS) Journal of Neuroimmunology. ,vol. 222, pp. 82- 86 ,(2010) , 10.1016/J.JNEUROIM.2010.02.014
Elliot M. Frohman, Michael K. Racke, Cedric S. Raine, Multiple Sclerosis — The Plaque and Its Pathogenesis New England Journal of Medicine. ,vol. 354, pp. 942- 955 ,(2006) , 10.1056/NEJMRA052130
Glen Jickling, Boryana Stamova, Isaac N Pessah, Paul Ashwood, Peter G. Green, Jeffrey Gregg, Robin L Hansen, Irva Hertz-Picciotto, Judith A Van de Water, Yingfang Tian, Frank R Sharp, Xiaowei Yang, Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls Neurotoxicity Research. ,vol. 19, pp. 1- 13 ,(2011) , 10.1007/S12640-009-9126-X