COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women

摘要: We hypothesised that biomass smoke exposure is associated with an airway-predominant chronic obstructive pulmonary disease (COPD) phenotype, while tobacco-related COPD emphysema-predominant phenotype. In this cross-sectional study, female never-smokers and (n=21) ex-cigarette smokers without (n=22) completed computed tomography (CT) at inspiration expiration, function, blood gas, exercise tolerance, quality of life measures. Two radiologists scored the extent emphysema air trapping on CT. Quantitative severity distribution airway wall thickness were calculated using specialised software. Women in tobacco group had significantly more than (radiologist score 2.3 versus 0.7, p=0.001; CT 27% 19%, p=0.046; a larger size emphysematous spaces, p=0.006). 2.6 1.5, respectively; p=0.02) also lower symptom, activities confidence domains assessment oxygen saturation rest during (p<0.05). Biomass less but exposure, suggesting