Sex-of-offspring-specific transmission ratio distortion on mouse chromosome X.
作者： Elena De La Casa-Esperón , Carmen Sapienza , Tammi L. Briscoe , Andrei E. Verner , Fernando Pardo-Manuel De Villena
DOI: 10.1093/GENETICS/154.1.343
关键词:
摘要: During our study of the DDK syndrome, we observed sex ratio distortion in favor males among offspring F(1) backcrosses between C57BL/6 and strains. We also significant reproducible transmission inheritance alleles at loci on chromosome X female but not male (C57BL/6 x DDK)F(1) (C57BL/6-Pgk1(a) backcrosses. The is maximum DXMit210 central region decreases progressively proximal distal loci, a manner consistent with predictions single distorted locus model. closely linked to two distortion-controlling (Dcsx1 Dcsx2) described previously interspecific Our analysis suggests that female-offspring-specific observe likely be result death embryos particular genotypic combinations. In addition, confirm previous suggestion loss embryos.
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