作者: Thierry Frébourg , Bertrand Delpech , Eric Bercoff , Jacques Senant , Philippe Bertrand
关键词:
摘要: It has been suggested that glycosaminoglycans are involved in the pathogenesis of liver fibrosis. Furthermore, recent studies have reported one them, hyaluronate, was mainly taken up and degraded by liver. Using an enzymoimmunological assay, based on hyaluronate-hyaluronectin interaction, serum levels hyaluronate were measured 113 patients with various diseases. Patients divided into six groups according to clinical, biological histological data: Group 1-alcoholic cirrhosis (n = 47) including alcoholic hepatitis 24); 2-primary biliary 21); 3-cirrhosis related viral 10); 4-idiopathic hemochromatosis 17); 5-alcoholic fatty 8); 6-viral or drug acute 10). Ninety-four blood donors studied as controls. Levels found be strikingly elevated 1 (1,225 +/- 1,137 micrograms per liter), 2 (792 739 3 (649 373 4 (246 242 whereas 5 (94 63 liter) 6 (73 57 had values close controls (23 17 liter). There a significant correlation between albumin, prothrombin time, factor V concentration gamma-globulins. is reflect both active fibrosis hepatic failure may quantitative marker severity injury.