Serum hyaluronate in liver diseases: study by enzymoimmunological assay.

作者: Thierry Frébourg , Bertrand Delpech , Eric Bercoff , Jacques Senant , Philippe Bertrand

DOI: 10.1002/HEP.1840060310

关键词:

摘要: It has been suggested that glycosaminoglycans are involved in the pathogenesis of liver fibrosis. Furthermore, recent studies have reported one them, hyaluronate, was mainly taken up and degraded by liver. Using an enzymoimmunological assay, based on hyaluronate-hyaluronectin interaction, serum levels hyaluronate were measured 113 patients with various diseases. Patients divided into six groups according to clinical, biological histological data: Group 1-alcoholic cirrhosis (n = 47) including alcoholic hepatitis 24); 2-primary biliary 21); 3-cirrhosis related viral 10); 4-idiopathic hemochromatosis 17); 5-alcoholic fatty 8); 6-viral or drug acute 10). Ninety-four blood donors studied as controls. Levels found be strikingly elevated 1 (1,225 +/- 1,137 micrograms per liter), 2 (792 739 3 (649 373 4 (246 242 whereas 5 (94 63 liter) 6 (73 57 had values close controls (23 17 liter). There a significant correlation between albumin, prothrombin time, factor V concentration gamma-globulins. is reflect both active fibrosis hepatic failure may quantitative marker severity injury.

参考文章(18)
A Tengblad, Quantitative analysis of hyaluronate in nanogram amounts Biochemical Journal. ,vol. 185, pp. 101- 105 ,(1980) , 10.1042/BJ1850101
Carroll Moton Leevy, Sheila Sherlock, Hans Popper, Diseases of the liver and biliary tract : standardization of nomenclature, diagnostic criteria, and diagnostic methodology Castle House Publications Ltd. ,(1976)
J R F Fraser, T C Laurent, H Pertoft, E Baxter, Plasma clearance, tissue distribution and metabolism of hyaluronic acid injected intravenously in the rabbit Biochemical Journal. ,vol. 200, pp. 415- 424 ,(1981) , 10.1042/BJ2000415
Sigbritt Eriksson, J.Robert E. Fraser, Torvard C. Laurent, Håkan Pertoft, Bård Smedsrød, Endothelial cells are a site of uptake and degradation of hyaluronic acid in the liver Experimental Cell Research. ,vol. 144, pp. 223- 228 ,(1983) , 10.1016/0014-4827(83)90458-5
Bertrand Delpech, Catherine Halavent, Characterization and purification from human brain of a hyaluronic acid-binding glycoprotein, hyaluronectin. Journal of Neurochemistry. ,vol. 36, pp. 855- 859 ,(1981) , 10.1111/J.1471-4159.1981.TB01672.X
John T. Galambos, Martin A. Hollingsworth, Arthur Falek, W. Dean Warren, J. R. McCain, The Rate of Synthesis of Glycosaminoglycans and Collagen by Fibroblasts Cultured from Adult Human Liver Biopsies Journal of Clinical Investigation. ,vol. 60, pp. 107- 114 ,(1977) , 10.1172/JCI108746
Anna Engström-Laurent, Ulla B. G. Laurent, Karin Lilja, Torvard C. Laurent, Concentration of sodium hyaluronate in serum. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 45, pp. 497- 504 ,(1985) , 10.3109/00365518509155249
Anna Engström-Laurent, Lars Lööf, Anders Nyberg, Torbjörn Schröder, Increased serum levels of hyaluronate in liver disease. Hepatology. ,vol. 5, pp. 638- 642 ,(1985) , 10.1002/HEP.1840050420