Evidence for participation of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 (NGAL•MMP-9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth.
作者： Kara M. Rood , Irina A. Buhimschi , Katherine Rodewald Millen , Mert O. Bahtiyar , Stephen Thung
DOI: 10.1111/AJI.12523
关键词:
摘要: Problem Neutrophil gelatinase-associated lipocalin (NGAL) is expressed in neutrophils and involved innate immunity by sequestering iron. NGAL's ability to complex with matrix metalloproteinase-9 (MMP-9) extend its gelatinolytic activity led us investigate role pregnancies complicated preterm birth (PTB) intra-amniotic infection/inflammation (IAI). Method of study We assayed the amniotic fluid (AF) levels NGAL MMP-9 308 women that had a clinically indicated amniocentesis normal pregnancy outcome or PTB. qRT-PCR was employed determine mRNA expression placental villous trophoblast amniochorion. Immunohistochemistry used for cellular localization. Results AF were gestational age-regulated. Women IAI PTB significantly higher NGAL, NGAL•MMP-9 complex. Conclusion The amniochorion source similarly other inflammatory conditions, this protein may augment collagenolytic effect modulate host–microbe interactions IAI.
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