Cardiovascular Actions of Neurotrophins

摘要: Neurotrophins were christened in consideration of their actions on the nervous system and, for a long time, they exclusive interest neuroscientists. However, more recently, this family proteins has been shown to possess essential cardiovascular functions. During development, neurotrophins and receptors are factors formation heart critical regulator vascular development. Postnatally, control survival endothelial cells, smooth muscle cardiomyocytes regulate angiogenesis vasculogenesis, by autocrine paracrine mechanisms. Recent studies suggest capacity neurotrophins, via tropomyosin-kinase receptors, promote therapeutic neovascularization animal models hindlimb ischemia. Conversely, neurotrophin low-affinity p75NTR receptor induces apoptosis cells impairs angiogenesis. Finally, nerve growth factor looks particular...