Integrin signalling regulates YAP and TAZ to control skin homeostasis

摘要: The skin is a squamous epithelium that continuously renewed by population of basal layer stem/progenitor cells and can heal wounds. Here, we show the transcription regulators YAP TAZ localise to nucleus in are elevated upon wound healing. Skin-specific deletion both adult mice slows proliferation cells, leads hair loss impairs regeneration after wounding. Contact with extracellular matrix consequent integrin-Src signalling key determinant nuclear localisation YAP/TAZ tumours. basement membrane lost differentiating daughter where become mostly cytoplasmic. In other types epithelia cell carcinomas, similar control mechanism present. By contrast, columnar differentiate an apical domain recruits CRB3, Merlin (also known as NF2), KIBRA WWC1) SAV1 induce Hippo retain cytoplasm despite contact matrix. When epithelial tumours lose their invasive, becomes tumour growth sensitive Src inhibitor Dasatinib.