Impact of Hemoglobin Drop, Bleeding Events, and Red Blood Cell Transfusions on Long-term Mortality in Patients Undergoing Transaortic Valve Implantation

作者: Maayan Konigstein , Ofer Havakuk , Yaron Arbel , Ariel Finkelstein , Eyal Ben-Assa

DOI: 10.1016/J.CJCA.2015.10.032

关键词:

摘要: Abstract Background Despite the minimally invasive nature of transcatheter aortic valve implantation (TAVI), procedure is associated with several complications. We aimed to analyze individual impact bleeding events, hemoglobin (Hb) drop, and red blood cell (RBC) transfusions on prognosis evaluate temporal trends in RBC since initiation TAVI program our centre onward. Methods Consecutive patients (n = 597) undergoing transfemoral were prospectively enrolled. Periprocedural Hb levels, transfusions, major/life-threatening events documented analyzed. Results In entire cohort, mean level decreased after (11.8 ± 1.4 9.5 1.3 g/dL; P  = 0.004). Among an drop ≥ 3 g/dL, had no significant survival (HR, 1.5; 95% CI, 0.7-2.9; 0.2); however, who received a significantly higher mortality 4.1; 2.2-7.7; Conclusions An frequently observed TAVI. are strongly increased long-term these patients, regardless degree or major bleeding.

参考文章(28)
Adam C. Salisbury, Kimberly J. Reid, Steven P. Marso, Amit P. Amin, Karen P. Alexander, Tracy Y. Wang, John A. Spertus, Mikhail Kosiborod, Blood Transfusion During Acute Myocardial Infarction: Association With Mortality and Variability Across Hospitals Journal of the American College of Cardiology. ,vol. 64, pp. 811- 819 ,(2014) , 10.1016/J.JACC.2014.05.040
Philippe Généreux, David J. Cohen, Mathew R. Williams, Michael Mack, Susheel K. Kodali, Lars G. Svensson, Ajay J. Kirtane, Ke Xu, Thomas C. McAndrew, Raj Makkar, Craig R. Smith, Martin B. Leon, Bleeding Complications After Surgical Aortic Valve Replacement Compared With Transcatheter Aortic Valve Replacement Journal of the American College of Cardiology. ,vol. 63, pp. 1100- 1109 ,(2014) , 10.1016/J.JACC.2013.10.058
Chun Shing Kwok, Matthew W. Sherwood, Sarah M. Watson, Samina B. Nasir, Matt Sperrin, Jim Nolan, Tim Kinnaird, Songsak Kiatchoosakun, Peter F. Ludman, Mark A. de Belder, Sunil V. Rao, Mamas A. Mamas, Blood Transfusion After Percutaneous Coronary Intervention and Risk of Subsequent Adverse Outcomes: A Systematic Review and Meta-Analysis. Jacc-cardiovascular Interventions. ,vol. 8, pp. 436- 446 ,(2015) , 10.1016/J.JCIN.2014.09.026
Michael Gotzmann, Anja Thiessen, Michael Lindstaedt, Andreas Mügge, Aydan Ewers, Left Atrial Diameter, Aortic Mean Gradient, and Hemoglobin for Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Implantation Clinical Cardiology. ,vol. 36, pp. 228- 234 ,(2013) , 10.1002/CLC.22100
Thomas Pilgrim, Stefan Stortecky, Fabienne Luterbacher, Stephan Windecker, Peter Wenaweser, Transcatheter aortic valve implantation and bleeding: incidence, predictors and prognosis Journal of Thrombosis and Thrombolysis. ,vol. 35, pp. 456- 462 ,(2013) , 10.1007/S11239-012-0842-3
Rutger-Jan M. Nuis, Nicolas M. Van Mieghem, Apostolos Tzikas, Nicolo Piazza, Amber M. Otten, Jin Cheng, Ron T. van Domburg, Michiel Betjes, Patrick W. Serruys, Peter P.T. de Jaegere, Frequency, determinants, and prognostic effects of acute kidney injury and red blood cell transfusion in patients undergoing transcatheter aortic valve implantation. Catheterization and Cardiovascular Interventions. ,vol. 77, pp. 881- 889 ,(2011) , 10.1002/CCD.22874
Milo C Engoren, Robert H Habib, Anoar Zacharias, Thomas A Schwann, Christopher J Riordan, Samuel J Durham, Effect of blood transfusion on long-term survival after cardiac operation The Annals of Thoracic Surgery. ,vol. 74, pp. 1180- 1186 ,(2002) , 10.1016/S0003-4975(02)03766-9
Didier Tchetche, Robert M.A. Van der Boon, Nicolas Dumonteil, Alaide Chieffo, Nicolas M. Van Mieghem, Bruno Farah, Gill L. Buchanan, Redouane Saady, Bertrand Marcheix, Patrick W. Serruys, Antonio Colombo, Didier Carrie, Peter P.T. De Jaegere, Jean Fajadet, Adverse impact of bleeding and transfusion on the outcome post-transcatheter aortic valve implantation: Insights from the Pooled-RotterdAm-Milano-Toulouse In Collaboration Plus (PRAGMATIC Plus) initiative American Heart Journal. ,vol. 164, pp. 402- 409 ,(2012) , 10.1016/J.AHJ.2012.07.003
Philippe Genereux, Lars Svensson, Susheel Kodali, Mathew Williams, Jeffrey Moses, Michael Mack, D. Craig Miller, E. Murat Tuzcu, John Webb, Craig Smith, Martin Leon, INCIDENCE, PREDICTORS AND IMPACT OF BLEEDING EVENTS AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR) COMPARED TO SURGICAL AORTIC VALVE REPLACEMENT (SAVR): INSIGHTS FROM THE PARTNER TRIAL Journal of the American College of Cardiology. ,vol. 59, pp. E2- ,(2012) , 10.1016/S0735-1097(12)60003-5
Nicolas M. Van Mieghem, Rutger-Jan Nuis, Apostolos Tzikas, Nicolo Piazza, Carl Schultz, Patrick W. Serruys, Peter P. de Jaegere, Prevalence and prognostic implications of baseline anaemia in patients undergoing transcatheter aortic valve implantation. Eurointervention. ,vol. 7, pp. 184- 191 ,(2011) , 10.4244/EIJV7I2A32