Expression of the Multidrug Resistance Gene (MDR1) in Non-small Cell Lung Cancer
作者： Yoshiyuki Abe , Masato Nakamura , Eiichiro Ota , Yuichi Ozeki , Seiichi Tamai
DOI: 10.1111/J.1349-7006.1994.TB02392.X
关键词:
摘要: To ezamine the clinical relevance of P-glycoprotein, encoded by human multidrug resistance gene (MDR1), to in lung cancer, we examined expression MDR1 107 non-small cell cancer (NSCLC) specimens and 20 corresponding normal tissues. We also evaluated relationship between histopathology pathological staging NSCLC. The tumors consisted 60 adenocarcinomas, 38 squamous carcinomas, 8 large 1 adenosquamous carcinoma. was semi-quantified use reverse transcriptase-polymerase chain reaction method. subclassified NSCLC into 3 grades according level (-, +, ++). Sixty-one tumor (57%) 18 tissue (90%) expressed various levels gene. Only one specimen showed higher than tissue. stage not significant. These results suggest that cells is decreased as progress from transformed state.
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