Prognostic value of fluorine18 flourodeoxyglucose positron emission tomography/computed tomography in dogs with appendicular osteosarcoma.

摘要: BACKGROUND Factors indicative of a negative prognosis for appendicular osteosarcoma (OSA) in dogs are visible metastatic disease, location, and size lesion. In human medicine maximum standard uptake value (SUVmax ), as measured on fluorine18 flourodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT), is prognostic survival several tumor types. OBJECTIVE Determine if SUVmax associated with progression-free interval (PFI) determination OSA. ANIMALS Sixty-two untreated OSA that had been staged 18 PET/CT. METHODS Retrospective analysis the PET/CT was performed. Dogs were excluded from study they did not receive definitive intent treatment their primary adjuvant chemotherapy carboplatin, or disease initial imaging. A region interest (ROI) created around to measure . Univariable multivariable Cox proportional hazards performed evaluate associations between variables including outcome PFI overall (OS). RESULTS Maximum significantly OS (P = .04) adjustment type monocyte count. The median time (OST) 284 days (range, 39-1293 days) OST having an ≥7.4 254 days 98-428 days) <7.4 680 days 108-811 days, P = .01). CONCLUSIONS AND CLINICAL IMPORTANCE via high being indicator prognosis.