microRNA inhibitors: Natural and artificial sequestration of microRNA.
作者： Li Tang , Hong-Yan Chen , Ning-Bo Hao , Bo Tang , Hong Guo
DOI: 10.1016/J.CANLET.2017.05.025
关键词:
摘要: MicroRNA (miRNAs) is post-transcriptional regulator of mRNA. However, the prevalence and activity miRNA are regulated by other regulators. inhibitors natural or artificial RNA transcripts that sequestrate miRNAs decrease even eliminate activity. Competing endogenous RNAs (ceRNAs) intracellular compete to bind shared recognition elements (MREs) microRNA availability relieve repression target RNAs. In recent years, studies have revealed ceRNA crosstalk involved in many pathophysiological processes adds a new dimension regulation. Artificial synthesized via chemical genetic methods. can be used loss-of-function research gene therapies for certain diseases. this review, we summarize advances two different types inhibitors.
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