Intracranial injury acutely induces the expression of the secreted isoform of the CNS-specific hyaluronan-binding protein BEHAB/brevican.

摘要: Hyaluronan (HA) plays an important role in tissue reorganization response to injury. The mechanisms by which HA participates these processes are likely include HA-binding proteins. Previously, we reported the cloning and initial characterization of a central nervous system (CNS)-specific protein, BEHAB (brain enriched hyaluronan binding), was independently cloned another laboratory named brevican. BEHAB/brevican mRNA is expressed ventricular zone coincident with proliferation migration glial cells surgical samples human glioma, where glial-derived proliferate migrate. To determine whether also during cellular associated CNS injury, have examined expression reactive gliosis. occurs as secreted cell-surface, glycosylphosphatidylinositol (GPI)-anchored, isoforms. secreted, but not GPI-anchored, isoform up-regulated stab wound adult rat brain. temporal regulation spatial distribution parallel gliotic intermediate filament protein nestin. up-regulation injury suggests for this extracellular matrix molecule Glial process extension, element may require reexpression both cytoskeletal elements that normally motility seen immature