Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: Correlation with proliferation

摘要: Vascular endothelial growth factor (VEGF) and its receptor Flk-1/KDR play an important role in vascular permeability tumor angiogenesis. Prompted by the hypothesis that VEGF/Flk-1 system may have regulatory roles breast carcinogenesis, we investigated expression of Flk-1 141 invasive carcinomas correlation with clinical immunohistochemical prognostic parameters, including proliferation indices like Ki-67 Topoisomerase IIalpha (Topo-IIalpha). The avidin-biotin-peroxidase method was performed on paraffin sections for detection Flk-1, p53, Bcl-2, c-erbB-2, Ki-67, Topo-IIalpha, ER, PR. detected 91 (64.5%) showing a widespread cytoplasmic most neoplastic cells. correlated menopausal status (P = 0.051) patient nuclear grade carcinoma 0.003), but demonstrated no histologic grade, stage, survival. It is interesting significant 2 well-established indices, 0.037) topo-IIalpha 0.009), whereas there PR, c-erbB-2. Moreover, showed inverse TIMP-1 mRNA localization intratumoral stromal cells 0.013). In conclusion, suggests VEGF exert activity mammary cancer through Flk-1. On other hand, supports notion inhibitory