ABCG2 regulates the pattern of self-renewing divisions in cisplatin-resistant non-small cell lung cancer cell lines.
作者： YING TANG , JINGMING HOU , GUANGHUI LI , ZONGCHANG SONG , XIAOJING LI
DOI: 10.3892/OR.2014.3470
关键词:
摘要: Overexpression of ABCG2 is considered a major mechanism cancer drug resistance. Recent studies have shown that can regulate the switch between symmetric and asymmetric cell division in adult stem cells; however, relationship drug-resistant cells remains to be determined. In present study, we demonstrated involved cells. We first established H460 A549 lines by repeated exposure cisplatin found expression these was significantly increased. As evidenced PKH-26 staining, favored division, which differed from parental Furthermore, stable ABCG2‑overexpressing shRNA-ABCG2‑knockdown evaluate potential role division. The results showed overexpression increased proportion whereas knockdown Taken together, our findings suggest modulation resistance regulating pattern study provides novel insight into treatment
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