摘要: During the course of purifying nerve growth factor from submaxillary gland mouse, Cohen (1960) and Levi-Montalcini noticed that daily injections certain extract fractions into newborn mice produced developmental changes could not be ascribed to factor. These included precocious opening eyelids (7 days compared usual 14 days) a similar early eruption incisors. Using these gross anatomical as an assay, (1962) proceeded isolate active — polypeptide which he termed epidermal (EGF).
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