Determination of Cellular Shape by the Extracellular Matrix and Its Correlation with the Control of Cellular Growth

摘要: Abstract Although the problem of cellular proliferation may seem at first glance to be tremendously complex, mechanisms which control it extremely simple. One primary factors regulates mitogenic response a given cell type class agents seems shape. We have found that corneal epithelial cells, for example, adopt flattened configuration when maintained in vitro on plastic and are very sensitive fibroblast growth factor, but not epidermal factor. When collagen, other hand, they become tall columnar respond primarily The shape is dictated by extracellular material upon cells rest substrate maintained. itself may, turn, induce manufacture their specific surface proteins