A crispr/cas system-based novel fusion protein and its application in genome editing
作者： Guojun Zhao
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摘要: An inactive CRISPR/Cas system-based fusion protein and its applications in gene editing are disclosed. More particularly, chimeric proteins including an inCas fused to a DNA modifying enzyme methods of using the The can be used induce double-strand breaks single-strand nicks target DNAs, generate disruptions, deletions, point mutations, replacements, insertions, inversions other modifications genomic within cells organisms.
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