Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions
作者： Kacoli Banerjee , Shubhadeep Banerjee , Mahitosh Mandal
DOI: 10.1016/J.JCIS.2016.12.025
关键词:
摘要: Recent endeavors in exploiting vast array of natural phytochemicals to ameliorate colorectal cancer led us investigate apigenin, a naturally occurring dietary flavone as potential chemo-therapeutic agent. The present study focuses on establishing apigenin chemotherapeutic agent for alleviating and reports the development stable liposomal nanocarrier with high encapsulation hydrophobic enhanced effects. pharmacological activity has been assigned its ability interact subsequently influence membrane properties which also resulted optimal yield stable, rigidified, non-leaky nano-carrier ideal release kinetics. Extensive testing drug counterpart clinical applications yielded hemocompatibility cytocompatibility normal fibroblast cells while antineoplastic was observed tumor xenograft model. increased highlights apigenin-based vesicles.
harvard.edu
sci-hub.se 参考文章(24)
Weiqun Wang, Laura Heideman, Chilly S. Chung, Jill C. Pelling, Kenneth J. Koehler, Diane F. Birt, Cell-Cycle Arrest at G2/M and Growth Inhibition by Apigenin in Human Colon Carcinoma Cell Lines Molecular Carcinogenesis. ,vol. 28, pp. 102- 110 ,(2000) , 10.1002/1098-2744(200006)28:2<102::AID-MC6>3.0.CO;2-2
Shubhadeep Banerjee, Kacoli Sen, Tapan K. Pal, Sujoy K. Guha, Poly(styrene-co-maleic acid)-based pH-sensitive liposomes mediate cytosolic delivery of drugs for enhanced cancer chemotherapy International Journal of Pharmaceutics. ,vol. 436, pp. 786- 797 ,(2012) , 10.1016/J.IJPHARM.2012.07.059
Weiqun Wang, Peter C. VanAlstyne, Kimberly A. Irons, She Chen, Jeanne W. Stewart, Diane F. Birt, Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutrition and Cancer. ,vol. 48, pp. 106- 114 ,(2004) , 10.1207/S15327914NC4801_14
Kacoli Sen, Shubhadeep Banerjee, Mahitosh Mandal, Abstract 4594: Reversal of Warburg effect by Apigenin and 5-Fluorouracil loaded dual drug liposomes result in enhanced colorectal chemotherapy Cancer Research. ,vol. 74, pp. 4594- 4594 ,(2014) , 10.1158/1538-7445.AM2014-4594
Wei-Chin Hung, Fang-Yu Chen, Chang-Chun Lee, Yen Sun, Ming-Tao Lee, Huey W. Huang, Membrane-Thinning Effect of Curcumin Biophysical Journal. ,vol. 94, pp. 4331- 4338 ,(2008) , 10.1529/BIOPHYSJ.107.126888
Jeffrey Barry, Michelle Fritz, Jeffrey R. Brender, Pieter E. S. Smith, Dong-Kuk Lee, Ayyalusamy Ramamoorthy, Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. Journal of the American Chemical Society. ,vol. 131, pp. 4490- 4498 ,(2009) , 10.1021/JA809217U
Kacoli Sen, Mahitosh Mandal, Second generation liposomal cancer therapeutics: Transition from laboratory to clinic International Journal of Pharmaceutics. ,vol. 448, pp. 28- 43 ,(2013) , 10.1016/J.IJPHARM.2013.03.006
Fredrik Ollila, Katrin Halling, Pia Vuorela, Heikki Vuorela, J.Peter Slotte, Characterization of Flavonoid–Biomembrane Interactions Archives of Biochemistry and Biophysics. ,vol. 399, pp. 103- 108 ,(2002) , 10.1006/ABBI.2001.2759
Kacoli Banerjee, Shubhadeep Banerjee, Subhayan Das, Mahitosh Mandal, None, Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss. Journal of Colloid and Interface Science. ,vol. 453, pp. 48- 59 ,(2015) , 10.1016/J.JCIS.2015.04.030
Kristin M Nieman, Hilary A Kenny, Carla V Penicka, Andras Ladanyi, Rebecca Buell-Gutbrod, Marion R Zillhardt, Iris L Romero, Mark S Carey, Gordon B Mills, Gökhan S Hotamisligil, S Diane Yamada, Marcus E Peter, Katja Gwin, Ernst Lengyel, None, Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth Nature Medicine. ,vol. 17, pp. 1498- 1503 ,(2011) , 10.1038/NM.2492