Oncogenes: Implications for the Diagnosis and Treatment of Cancer

摘要: Cellular oncogenes comprise a small family of genes, highly conserved throughout vertebrate evolution, that code for proteins with diverse functions including DNA binding, protein kinase, and cellular growth factor activities. are important in certain aspects the proliferation differentiation normal cells. Under some circumstances these genes may also induce malignant transformation Various mechanisms underlie their involvement carcinogenesis. Incorporation all, or part of, into RNA tumor viruses, mutations gene structure, translocation from one chromosome to another all be associated induction change In situations altered oncogene products made. Knowledge about biology lead improved techniques cancer detection perhaps new approaches treatment.