Aging, comorbidities, and the importance of finding biomarkers for HIV-associated neurocognitive disorders

作者: Jacqueline Rosenthal , William Tyor

DOI: 10.1007/S13365-019-00735-0

关键词:

摘要: HIV-associated neurocognitive disorders (HAND) continue to affect a large proportion of persons living with HIV despite effective viral suppression combined antiretroviral therapy (cART). Importantly, milder versions HAND have become more prevalent. The pathogenesis in the era cART appears be multifactorial contributions from central nervous system (CNS) damage that occur prior starting cART, chronic immune activation, neurotoxicity, and various age-related comorbidities (i.e., cardiovascular cerebrovascular disease, diabetes, hyperlipidemia). Individuals may experience premature aging, which could also contribute cognitive impairment. Likewise, degenerative aside increase age there is evidence shared pathology between other neurodegenerative diseases, such as Alzheimer’s can or without co-existing HAND. Given aforementioned complex interactions associated HIV, impairment, it important consider an age-appropriate differential diagnosis for HIV-positive population continues grow older. These factors make accuracy reliability mild forms aging HIV-infected individuals challenging. complexity current highlights need develop reliable biomarkers. Ultimately, identification set specific biomarkers will required achieve early accurate diagnosis, necessary assuming treatments are developed.

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