Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis
作者： Hemant K Roy , Ramesh K Wali , Young Kim , Yang Liu , John Hart
DOI: 10.1016/J.FEBSLET.2007.07.012
关键词:
摘要: We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase supply (EIBS) is a hallmark of colon carcinogenesis. In the current study, we elucidate mechanism EIBS by assessing iNOS/nitric oxide axis histologically normal colonic mucosa rats treated with colon-specific carcinogen, azoxymethane. demonstrate there was strong temporal correlation between and iNOS expression/activity. Importantly, also observed short-term treatment nitric inhibitor abrogated EIBS. These data indicate induction may critical role augmenting predysplastic thereby fostering
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