Targeting microvasculature for neuroprotection after SCI.

摘要: Spinal cord injury (SCI) is characterized by secondary degeneration, which leads to tissue loss at the epicenter and subsequent functional deficits. This review provides insight into pathophysiology of microvascular dysfunction endothelial cell loss, are among earliest responses during first postinjury day. The enigmatic role angiogenic response in penumbra around lost tissue, occurs 2 weeks, also discussed. importance stabilizing rescuing injured vasculature now well-recognized, several pharmacological genetic treatments have emerged past few years. We conclude with suggestions for future experimental research, including development vascular-selective exploitation models. In summary, vascular following SCI an important contributor neurological deficits, as proposed long ago. However, there appears be new potentially powerful opportunities treating acute targeting responses.