Tumor characteristics as predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis

摘要: While ductal carcinoma in situ (DCIS) is seldom life threatening, the management of DCIS remains a dilemma for patients and their physicians. Aggressive treatment reduces risk ipsilateral breast tumor recurrence (IBTR), but has never been proven to improve survival. There interest identifying prognostic factors determining low-risk patients, comprehensive review high-quality evidence on characteristics predicting local carried out. We examined following characteristics: biomarkers, comedonecrosis, focality, surgical margin, method detection, grade, size. For this systematic we restricted analyses results subgroup from randomized controlled trials (RCTs) multivariate RCTs observational studies. identified 44 eligible articles. The pooled random-effects estimates IBTR are comedonecrosis 1.71(95% CI, 1.36–2.16), focality 1.95(95% 1.59–2.40), margin 2.25(95% 1.77–2.86), detection 1.35(95% 1.12–1.62), grade 1.81(95% 1.53–2.13), size 1.63(95% 1.30–2.06). Limited indicated that women whose ER-negative, PR-negative, or HER2/neu receptor positive have an higher than those ER-positive, PR-positive, negative. A variety significant predictors IBTR. These important both clinicians interpret decide course treatment.