Matrix metalloproteinase and tissue inhibitors of metalloproteinase secretion by haematopoietic and stromal precursors and their production in normal and leukaemic long-term marrow cultures.
作者： L. A. Marquez-Curtis , A. Dobrowsky , J. Montaño , A. R. Turner , J. Ratajczak
DOI: 10.1046/J.1365-2141.2001.03160.X
关键词:
摘要: Matrix metalloproteinases (MMPs) and tissue inhibitors of (TIMPs) regulate the turnover extracellular matrix may modulate biology haematopoietic cells. We investigated whether MMPs TIMPs are produced in long-term marrow cultures (LTMCs) established from normal donors acute myelogenous leukaemia (AML) patients, by fibroblast- (F), granulocyte macrophage- (GM) megakaryocyte- (Meg) colony-forming unit (CFU) erythroid burst-forming (BFU-E)-derived precursor ProMMP-9 levels were highest (> 400 ng/ml) at week 1 LTMC, whereas proMMP-2, TIMP-1, TIMP-2 TIMP-3 peaked (up to 1000 after establishment adherent layer. In LTMC AML these patterns secretion reversed. Moreover, we found that a 24 h incubation serum-free media, CFU-GM-, BFU-E- CFU-Meg-derived cells secreted proMMP-9 CFU-F-derived contrast layer which both active latent forms MMP-2 MMP-9 under conditions. However, when incubated 12.5% fetal calf or horse serum complete growth no longer detectable, TIMP increased. Hence, concluded (i) MMPs/TIMPs human bone stromal play an important role intercellular cross-talk haematopoiesis; (ii) only present conditions, indicating specific media used for weekly re-feeding can block activation MMP-9, maintaining integrity supporting haematopoiesis vitro.
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