The proliferative immune response to autologous Epstein-Barr virus-transformed lymphoblastoid cells. I. Studies with HLA haplotype loss variants demonstrate a role for MHC-linked genes
作者： Pamela J. Reitnauer , Robert DeMars , Paul M. Sondel
DOI: 10.1016/0198-8859(85)90010-2
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摘要: Abstract The human Epstein-Barr virus transformed lymphoblastoid cell line (EBV-LCL) 721 and MHC haplotype loss variants derived from it were utilized to dissect the functional role of genes in proliferative response autologous T lymphocytes EBV-LCL. LCL-721 is heterozygous at all phenotypically defined loci. One type variant expresses only determinants encoded by maternal (m) other paternal (p) haplotype. Autologous (individual A) primary responses are strong each deletant. tertiary priming comparison relatively weak reciprocal indicate that linked important Similar specific observed when peripheral blood (PBLs) donor's mother used as responding cells. Allogeneic also studied PBLs unrelated donors with deletants. Quantitative comparisons proliferation primed allogeneic stimulated irradiated donor A her mother, its variants, show some involve recognition EBV-LCL while detect alloantigens.
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