Isolation and characterization of 3-methoxy-2(5H)-furanone as the principal nephrotoxin fromNarthecium ossifragum (L.) Huds.
作者： Wenche Langseth , Trine Torgersen , Per Kolsaker , Christian Rømming , Tor Gunnar Jantsch
DOI: 10.1002/(SICI)1522-7189(199905/06)7:3<111::AID-NT48>3.0.CO;2-F
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摘要: The principal substance in Narthecium ossifragum (L.) Huds, responsible for the nephrotoxic effects on cattle, moose, goats and other ruminants has been isolated identified by X-ray crystallography as 3-methoxy-2(5H)-furanone. Fourier-transform infra-red, 1H 13C nuclear magnetic resonance, mass spectra are also given. concentration four different batches of plant material varied from 113 to 344 microg g(-1) (wet weight). Extracts N. fractions derived them, including purified 3-methoxy-2(5H)-furanone, were each dosed intraruminally, young goats. 3-Methoxy-2(5H)-furanone 99.9% purity (15 mg kg(-1) live weight) caused increased creatinine serum within 2-3 days, typical kidney damage ossifragum, while toxic effect was obtained down 4 weight with less (> or = 95%). Toxic synthesized 3-methoxy-2(5H)-furanone (30 isomer 4-methoxy-2(5H)-furanone, detected some material, not when at 60 weight.
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