Biology of Colorectal Cancer
作者： Muhammad Wasif Saif , Edward Chu
DOI: 10.1097/PPO.0B013E3181E076AF
关键词:
摘要: Significant advances have been made in understanding the biology of colorectal cancer. In this chapter, we review key signaling pathways that play roles maintaining growth and proliferation The will be discussed include Wnt/beta-catenin, TGF-beta/SMAD, Notch, Hedgehog, epidermal factor receptor, Ras, PI3K/Akt. addition, growing role colon cancer stem cells mediating cellular drug resistance recurrence. This enhanced provides important insights for developing novel therapies target specific receptors and/or certain critical signal transduction pathways. These targeted can then used alone or combination with standard cytotoxic chemotherapy regimens.
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