Multidrug resistance-associated protein MRP1 expression in human gliomas: chemosensitization to vincristine and etoposide by indomethacin in human glioma cell lines overexpressing MRP1.

摘要: The 190 kDa multidrug resistance protein MRP1 is likely to be involved in the phenotype of human gliomas. expression was evaluated surgical tumor samples from 17 patients with In addition, impact MRP's inhibitor, indomethacin, on chemosensitivity etoposide (VP16) and vincristine (VCR) two glioblastoma cell lines expressing (GL15 8MG) investigated. When samples, observed all them more than 90% stained cells 14/15 high-grade also strongly expressed at membrane vascular endothelial same 14 suggesting that permeability anticancer drugs could limited across brain vessels. At concentrations comprised between 5 50 μM, indomethacin significantly increased cytotoxic effect both but it efficient increasing cytotoxicity VCR GL15 cells, as compared 8MG cells. These results suggest association or interest clinical management