Epigenetic Pathways and Glioblastoma Treatment: Insights from Signaling Cascades

摘要: There is an urgent need to identify novel therapies for glioblastoma (GBM) as most are ineffective. A first step in this process and validate targets therapeutic intervention. Epigenetic modulators have emerged attractive drug several cancers including GBM. These epigenetic regulators affect gene expression without changing the DNA sequence. Recent studies suggest that interact with drivers of GBM cell stem-like proliferation. include components Notch, Hedgehog, Wingless (WNT) pathways. We highlight recent connecting signaling pathways also review systems big data approaches identifying patient specific Collectively, these will combinations may be effective other cancers.