Helicobacter pyloriInfection in Children. Antimicrobial Resistance and Treatment Response

摘要: Background The aim of this study was to determine the appropriateness recent recommendations for managing Helicobacter pylori infection in children a university hospital Southern Europe. Antimicrobial resistance and response eradication therapy were also determined. Materials Methods The presence H. pylori studied 143 children: by gastric biopsy culture (GBC), 13C-urea breath test (UBT) stool antigen immunochromatography (SAIT) 56 children; GBC UBT 20, SAIT 18, alone 49. susceptibility determined E-test. Infection defined as positive or positivity both SAIT. Disease progression 118 patients. First evaluation symptoms carried out at 3–6 months after diagnosis and/or treatment infection. Results H. pylori detected 74 from analyzed (100% positive, 98.1% 58.1% positive). The main symptom chronic abdominal pain (n = 121). Macroscopic antral nodularity observed 29.7% infected patients 5.8% uninfected patients, respectively. Resistance clarithromycin metronidazole found 34.7 16.7%, Eradication when susceptible antimicrobials used occurred 78.7% (48/61) versus 37.5% (3/8) included drug with (p = .024). In recurrent pain, resolved 92.9% (39/42) HP 42.9% (6/14) without (p < .001). Conclusion Treated often failed meet criteria established guidelines diagnostic screening because most them had only but remission their associated eradication.