Pulmonary inflammation and immune responses during the course of Nippostrongylus brasiliensis infection: lymphocyte subsets in bronchoalveolar lavage fluids of rats.
作者： K. RAMASWAMY , D. BEFUS
DOI: 10.1111/J.1365-3024.1993.TB00611.X
关键词:
摘要: Summary Quantitative measurements were made of different phenotypes lymphocytes in bronchoalveolar lavage fluid (BALF) rats during the course a primary or secondary infection with Nippostrongylus brasiliensis. These changes compared those peripheral blood to understand site-specificity responses. Following infection, there was significant increase both B and T BALF. The CD4: CD8 ratio significantly altered decreased on day 2 increased days 16 32 post (p.i.). Two colour analysis showed that larval migration through lungs (day p.i.) CD8+, CD4+ OX22+ OX22- cells As progressed time, OX22 – significantly. Compared resulted recovery OX22– not readily appreciated blood, suggesting site-specific compartmentalization lymphocyte responses lung. functional significance these dynamic subsets airspaces following remains be identified.
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