Cell motility in fibroblast aggregates
作者： P.B. Armstrong , M.T. Armstrong
DOI: 10.1242/JCS.33.1.37
关键词:
摘要: The stable arrangements of cells in tissues and organs require that most tissue cells, whatever their inherent abilities for active pseudopod-directed locomotion, remain confined to the boundaries parent lifetime organism. Contact inhibition motility represents a potential mechanism immobilizing thus promoting positional stability. In order assess effectiveness contact 3-dimensional tissue-like masses, spherical aggregates chick heart, sclera skin fibroblasts were fused with tritiated thymidine-labelled identical cell type. After being placed contact, 2 cohere broaden area mutual form single aggregate planar interface between two. Mobility was detected by migration labelled across into unlabelled aggregate. Based on measurements distances moved day-old pairs, it found up 17 diameters 36% as far solid masses monolayer culture under optimal conditions directed migration.
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biologists.org参考文章(25)
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