XRCC1 gene polymorphisms and risk of neuroblastoma in Chinese children.
作者： Jiao Zhang , Zhenjian Zhuo , Wenya Li , Jinhong Zhu , Jing He
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摘要: Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. gene polymorphisms are being increasingly explored cancer epidemiology studies. However, contribution to neuroblastoma risk remains unclarified. Herein, we conducted case-control study 393 patients and 812 controls explore association (rs1799782 G>A, rs25487 C>T, rs25489 C>T rs915927 T>C) risk. Results showed none studied was associated individuals 2 genotypes seemed be at significantly higher for compared those without genotype (adjusted odds ratio=1.69; 95% confidence interval=1.06-2.69). Stratified analysis revealed CT/TT strongly reduced children ≤ 18 months age subgroup clinical stage I+II+4s diseases, CC genotypes. We also identified an increased carrier 2-3 among I+II+4s. More evidence between needed.
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