p53 gene analysis of ovarian borderline tumors and stage I carcinomas
作者： Jolanta Kupryjanczyk , Debra A Bell , Dino Dimeo , Roberta Beauchamp , Ann D Thor
DOI: 10.1016/0046-8177(95)90138-8
关键词:
摘要: Mutations of the p53 gene are common in human ovarian carcinomas; however, their role early development cancer is unclear. Twelve borderline tumors (BTs; eight them immunopositive) and 10 stage I carcinomas (four were studied for genetic alterations gene. The study was based on single-strand conformation polymorphism (SSCP) analysis DNA sequencing exons 2 through 11 using preparations from microdissected tumors. found 40% (including a component adjacent to carcinoma one lesion) but none pure BTs. These findings suggest that mutations may not be commonly associated with phenotype epithelial occur during malignant transformation.
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