Increased decision thresholds enhance information gathering performance in juvenile Obsessive-Compulsive Disorder (OCD)

作者: Tobias U. Hauser , Michael Moutoussis , Reto Iannaccone , Silvia Brem , Susanne Walitza

DOI: 10.1371/JOURNAL.PCBI.1005440

关键词:

摘要: Patients with obsessive-compulsive disorder (OCD) can be described as cautious and hesitant, manifesting an excessive indecisiveness that hinders efficient decision making. However, excess caution in making may also lead to better performance specific situations where the cost of extended deliberation is small. We compared 16 juvenile OCD patients matched healthy controls whilst they performed a sequential information gathering task under different external conditions. found outperformed controls, winning significantly more points. The groups differed number draws required prior committing decision, but not accuracy. A novel Bayesian computational model revealed subjective sampling costs arose non-linear function sampling, closely resembling escalating urgency signal. Group difference was best explained by later emergence these group, evident increased threshold. Our findings present suggest enhanced accounted for higher threshold arising out altered perception that, some contexts, advantageous.

参考文章(73)
Christopher J. C. H. Watkins, Peter Dayan, Technical Note : \cal Q -Learning Machine Learning. ,vol. 8, pp. 279- 292 ,(1992) , 10.1007/BF00992698
Christina Andreou, Brooke C. Schneider, Vivien Braun, Katharina Kolbeck, Jürgen Gallinat, Steffen Moritz, Dopamine effects on evidence gathering and integration Journal of Psychiatry & Neuroscience. ,vol. 40, pp. 422- 428 ,(2015) , 10.1503/JPN.140306
Pamela Jacobsen, Daniel Freeman, Paul Salkovskis, Reasoning bias and belief conviction in obsessive-compulsive disorder and delusions: Jumping to conclusions across disorders? British Journal of Clinical Psychology. ,vol. 51, pp. 84- 99 ,(2012) , 10.1111/J.2044-8260.2011.02014.X
Christopher J.C.H. Watkins, Peter Dayan, Technical Note Q-Learning Machine Learning. ,vol. 8, pp. 279- 292 ,(1992) , 10.1023/A:1022676722315
Robert A Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A Rietveld, Abdel Abdellaoui, Michel M Nivard, Magnus Johannesson, Tessel E Galesloot, Jouke J Hottenga, Gonneke Willemsen, David Cesarini, Daniel J Benjamin, Patrik KE Magnusson, Fredrik Ullén, Henning Tiemeier, Albert Hofman, Frank JA Van Rooij, G Bragi Walters, Engilbert Sigurdsson, Thorgeir E Thorgeirsson, Andres Ingason, Agnar Helgason, Augustine Kong, Lambertus A Kiemeney, Philipp Koellinger, Dorret I Boomsma, Daniel Gudbjartsson, Hreinn Stefansson, Kari Stefansson, None, Polygenic risk scores for schizophrenia and bipolar disorder predict creativity Nature Neuroscience. ,vol. 18, pp. 953- 955 ,(2015) , 10.1038/NN.4040
T. U. Hauser, L. T. Hunt, R. Iannaccone, S. Walitza, D. Brandeis, S. Brem, R. J. Dolan, Temporally dissociable contributions of human medial prefrontal subregions to reward-guided learning The Journal of Neuroscience. ,vol. 35, pp. 11209- 11220 ,(2015) , 10.1523/JNEUROSCI.0560-15.2015
Jonathan D. Huppert, H. Blair Simpson, Kore J. Nissenson, Michael R. Liebowitz, Edna B. Foa, Quality of life and functional impairment in obsessive–compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls Depression and Anxiety. ,vol. 26, pp. 39- 45 ,(2009) , 10.1002/DA.20506
Sarah Fischer, Gregory T. Smith, Binge eating, problem drinking, and pathological gambling: Linking behavior to shared traits and social learning Personality and Individual Differences. ,vol. 44, pp. 789- 800 ,(2008) , 10.1016/J.PAID.2007.10.008