The avian B‐cell receptor complex: distinct roles of Igα and Igβ in B‐cell development
作者： Kelly A. Pike , Ehtesham Baig , Michael J. H. Ratcliffe
DOI: 10.1111/J.0105-2896.2004.0111.X
关键词:
摘要: The bursa of Fabricius has evolved in birds as a gut-associated site B-cell lymphopoiesis that is segregated from the development other hematopoietic lineages. Despite differences developmental progression chicken compared to murine lymphopoiesis, cell-surface immunoglobulin (sIg) expression been conserved an essential checkpoint development. precursors express sIg complex includes evolutionarily Igalpha/beta heterodimer colonize lymphoid follicles bursa, whereas fail due non-productive V(D)J recombination are eliminated. Productive retroviral gene transfer allowed us introduce chimeric receptor constructs into developing vivo. Chimeric proteins comprising extracellular and transmembrane regions CD8alpha fused cytoplasmic domain Igalpha efficiently supported lacked endogenous expression. By contrast, equivalent containing Igbeta actively inhibited Consequently, domains play functionally distinct roles
sci-hub.se 参考文章(106)
A. M. Norment, D. R. Littman, A second subunit of CD8 is expressed in human T cells. The EMBO Journal. ,vol. 7, pp. 3433- 3439 ,(1988) , 10.1002/J.1460-2075.1988.TB03217.X
M. Takata, H. Sabe, A. Hata, T. Inazu, Y. Homma, T. Nukada, H. Yamamura, T. Kurosaki, Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. The EMBO Journal. ,vol. 13, pp. 1341- 1349 ,(1994) , 10.1002/J.1460-2075.1994.TB06387.X
Chong Fu, Christoph W. Turck, Tomohiro Kurosaki, Andrew C. Chan, BLNK: a Central Linker Protein in B Cell Activation Immunity. ,vol. 9, pp. 93- 103 ,(1998) , 10.1016/S1074-7613(00)80591-9
Claude-Agnés Reynaud, Barbara Bertocci, Auriel Dahan, Jean-Claude Weill, Formation of the Chicken B-Cell Repertoire: Ontogenesis, Regulation of Ig Gene Rearrangement, and Diversification by Gene Conversion Advances in Immunology. ,vol. 57, pp. 353- 378 ,(1994) , 10.1016/S0065-2776(08)60676-8
S H Hughes, J J Greenhouse, C J Petropoulos, P Sutrave, Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. Journal of Virology. ,vol. 61, pp. 3004- 3012 ,(1987) , 10.1128/JVI.61.10.3004-3012.1987
M S Schlissel, A L Shaffer, A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. Journal of Immunology. ,vol. 159, pp. 1265- 1275 ,(1997)
J.A. Taddie, T.R. Hurley, B.S. Hardwick, B.M. Sefton, Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta. Journal of Biological Chemistry. ,vol. 269, pp. 13529- 13535 ,(1994) , 10.1016/S0021-9258(17)36863-1
J.E. Hutchcroft, M.L. Harrison, R.L. Geahlen, Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. Journal of Biological Chemistry. ,vol. 267, pp. 8613- 8619 ,(1992) , 10.1016/S0021-9258(18)42487-8
S A Grupp, K Campbell, R N Mitchell, J C Cambier, A K Abbas, Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. Journal of Biological Chemistry. ,vol. 268, pp. 25776- 25779 ,(1993) , 10.1016/S0021-9258(19)74457-3
E Houssaint, Cell lineage segregation during bursa of Fabricius ontogeny. Journal of Immunology. ,vol. 138, pp. 3626- 3634 ,(1987)