A High Mobility Reactor Unit for R&D Continuous Flow Transfer Hydrogenations

摘要: A suitcase sized mobile reactor unit (MRU) weighing in at less than 10 kg was designed for laboratory scale transfer hydrogenations continuous flow. Simple cyclohexene and a cosolvent combination with palladium-on-charcoal packed bed provided setup isolation of nearly all products without the need further purification. Several functional groups including olefins, triple bonds, nitro-groups, carbonyls, so forth were effectively reduced retention times as low 2 min. Additionally, standard protection such Cbz, benzyl, allyl ether or esters removed high yields. To prove flexibility an example Mizoroki–Heck reaction also performed on MRU. Finally, two scale-up hydrogenation experiments affording desired target compounds 0.5 0.8 mol scales 4 h operation