Comparative analysis of the complete genome sequences of Kenyan African swine fever virus isolates within p72 genotypes IX and X
作者： Richard P. Bishop , Clare Fleischauer , Etienne P. de Villiers , Edward A. Okoth , Marisa Arias
DOI: 10.1007/S11262-014-1156-7
关键词:
摘要: Twelve complete African swine fever virus (ASFV) genome sequences are currently publicly available and these include only one sequence from East Africa. We describe sequencing annotation of a recent pig-derived p72 genotype IX, tick-derived X isolate Kenya using the Illumina platform comparison with 1950 isolate. The three genomes constitute cluster that was phylogenetically distinct other ASFV genomes, but 98-99 % conserved within group. Vector-based compositional analysis produced similar topology. Of 125 previously identified 'core' genes, two ORFs unassigned function were absent IX which 184 kb in size as compared to 191 for X. There multiple differences among 360 110 multicopy gene families. corresponding 360-19R has transposed 5' variable region both isolates. Additionally, there is ORF formed by fusion 13L 14L unique genomes. In future, functional based on variations families may reveal whether they contribute observed virulence between genotpye viruses.
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