Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.

摘要: ✓ The authors tested the hypothesis that proton magnetic resonance spectroscopy (1H-MRS) imaging can be used as a supportive diagnostic tool to differentiate clinically stable brain tumors from those progressing result of low- high-grade malignant transformation or posttherapeutic recurrence. Twenty-seven patients with cerebral gliomas verified on histological examination were studied repeatedly 1H-MRS over period 3.5 years. At time each study, clinical examination, MR imaging, positron emission tomography 18F-fluorodeoxyglucose, and biopsy findings (when available) categorize patient having either progressive disease. Measures percentage changes in choline (Cho) signal intensity between studies, which obtained without knowledge categorization, allowed investigators segregate groups high degree statistical significance. All cases showed Cho s...