Optimising Imaging Parameters for Post Mortem MR Imaging of the Human Brain

摘要: Purpose: MR imaging of post mortem brains has the potential to yield volumetric information and define extent structural changes prior pathological examination. Although standard T2-weighted clinical sequences have been used for examination formalin-fixed brains, these protocols may not optimum contrast. We examined effect varying durations formalin fixation on transverse relaxation time (T2) tissue spin density.Material Methods: Three were weekly during from unfixed state 35 days fixation. Standard spin-echo was at 5 echo times (20–100 ms) calculate density.Results: T2 decreased significantly (ANOVA, p<0.001) in both grey white matter by 7 there a further (but non-significant) trend towards lower values between days. Grey converged with Conversely, m...